The infection-tolerant mammalian reservoir of Lyme disease and other zoonoses broadly counters the inflammatory effects of endotoxin

• Published in: bioRxiv
• Main Authors: Balderrama-Gutierrez, Gabriela, Milovic, Ana, Cook, Vanessa J, M Nurul Islam, Zhang, Youwen, Kiaris, Hippokratis, Belisle, John T, Mortazavi, Ali, Barbour, Alan G
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.12.2020
• Subjects: Arginase; C-reactive protein; Corticosterone; Fibroblasts; Infections; Inflammation; Interleukin 10; Interleukin 12; Leukocytes (neutrophilic); Lipopolysaccharides; Lyme disease; Macrophages; Metabolomics; Morbidity; Nitric oxide; Nitric-oxide synthase; Oxidative stress; Pathogens; Proteinase; Proteinase inhibitors; Species; Spleen; Tryptophan; Zoonoses

ABSTRACT Animals that are competent natural reservoirs of zoonotic diseases commonly suffer little morbidity from the pathogens they persistently harbor. The mechanisms of this infection tolerance and the trade-off costs are poorly understood. We used exposure to a single dose of lipopolysaccharide...