S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

• Published in: bioRxiv
• Main Authors: Godbole, Adwait A, Gopalan, Sneha, Thein-Kim, Nguyen, Munden, Alexander L, Vo, Paula, Lewis, Caroline A, Spinelli, Jessica B, Fazzio, Thomas G, Amy Karol Walker
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 22.01.2023
• Subjects: Adenosylmethionine; Aging; Bioinformatics; Carbon cycle; DNA methylation; Gene expression; Heat stress; Life span; Metabolomics; Methionine; Phenotypes; S-Adenosylmethionine; Survival; Temperature effects

Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other processes. SAM is synthesized from methionine, which is imported or generated through the 1-carbon cycle (1CC). Alterations in 1CC function hav...