A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated super-enhancers

• Published in: bioRxiv
• Main Authors: Wang, Wenmeng, Qiao, Shiyao, Li, Guangyue, Yang, Cuicui, Chen, Zhong, Stovall, Daniel B, Shi, Jinming, Li, Dangdang, Sui, Guangchao
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.09.2021
• Subjects: Chromatin; DNA-directed RNA polymerase; Enhancers; Gene expression; Histidine; Histones; Kinases; RNA polymerase; YY1 protein

As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter connection. However, gaps still exist in understanding how YY1 coordinates coactivators and chromatin elements to assemble super-enhancers. Here, we demonstrate that YY1 activates FOXM1 gene expression through for...