Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

• Published in: bioRxiv
• Main Authors: Brummer, Alexander B, Xella, Agata, Woodall, Ryan, Adhikarla, Vikram, Cho, Heyrim, Gutova, Margarita B, Brown, Christine E, Rockne, Russell C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.12.2022
• Subjects: Cancer; Cell culture; Cell death; Cell therapy; Chimeric antigen receptors; Glioblastoma; Glioblastoma cells; Lymphocytes T; Mathematical models; Tumors

In the development of cell-based cancer therapies, quantitative mathematical models of cellular interactions are instrumental in understanding treatment efficacy. Efforts to validate and interpret mathematical models of cancer cell growth and death hinge first on proposing a precise mathematical mod...