mTORC1 activity is supported by spatial association with focal adhesions

• Published in: bioRxiv
• Main Authors: Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C, Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Oliver Dk Maddocks, Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 20.11.2020
• Subjects: Amino acids; Growth factors; Localization; Lysosomes; Rapamycin; TOR protein; United States > US

Abstract The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth factors involves recruitment of the complex to the lysosomal membrane and is further supported by lysosome distributi...