MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis

• Published in: bioRxiv
• Main Authors: Zouiouich, Mehdi, Thomas Di Mattia, Martinet, Arthur, Eichler, Julie, Wendling, Corinne, Tomishige, Nario, Grandgirard, Erwan, Fuggetta, Nicolas, Ramain, Catherine, Mizzon, Giulia, Dumesnil, Calvin, Carpentier, Maxime, Reina-San-Martin, Bernardo, Mathelin, Carole, Schwab, Yannick, Abdou, Rachid Thiam, Kobayashi, Toshihide, Drin, Guillaume, Tomasetto, Catherine, Alpy, Fabien
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.02.2022
• Subjects: Endoplasmic reticulum; Homeostasis; Lipids; Membrane proteins; Organelles

Membrane contact sites between organelles are organized by protein bridges. Among the components of these contacts, the VAP family comprises endoplasmic reticulum (ER)-anchored proteins, such as MOSPD2, functioning as major ER-organelle tethers. MOSPD2 distinguishes itself from the other members of...