B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses

• Published in: bioRxiv
• Main Authors: Hayward, Darryl, Vanes, Lesley, Wissmann, Stefanie, Sivapatham, Sujana, Hartweger, Harald, Joshua Biggs O'may, De Boer, Leon, Mitter, Richard, Kochl, Robert, Stein, Jens V, Tybulewicz, Victor Lj
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.09.2021
• Subjects: CD4 antigen; CD40 antigen; Cell activation; Cell migration; Chemokine receptors; CXCR5 protein; Immune response (humoral); Lymphocytes; Lymphocytes B; Lymphocytes T; Lymphoid tissue

Migration and adhesion play critical roles in B cells, regulating recirculation between lymphoid organs, migration within lymphoid tissue and interaction with CD4+ T cells. However, there is limited knowledge of how B cells integrate chemokine receptor and integrin signaling with B cell activation t...