Actl7b-deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis

• Published in: bioRxiv
• Main Authors: Merges, Gina Esther, Arevalo, Lena, Lohanadan, Keerthika, De Rooij, Dirk G, Jokwitz, Melanie, Witke, Walter, Schorle, Hubert
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 19.12.2022
• Subjects: Acrosomes; Actin; Alleles; Dynein; Immunoprecipitation; Infertility; Light chains; Spermatids; Spermatogenesis; Spermiogenesis

Actin-related proteins (Arp) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp and highly conserved in rodents and primates. ACTL7B is specifically expressed in round and elongating spermatids during spermiogenesis....