Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD

• Published in: bioRxiv
• Main Authors: Zhang, Ning, Kisiswa, Lilian, Ramanujan, Ajeena, Li, Zhen, Eunice Weiling Sim, Yuan, Wensu, Ibáñez, Carlos F, Lin, Zhi
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 08.02.2021
• Subjects: Adaptor proteins; Cell survival; Cerebellum; Granule cells; Intracellular signalling; Neurodegenerative diseases; NF-κB protein; NMR; Nuclear magnetic resonance; Recruitment; Signal transduction; Structure-function relationships

Abstract p75 neurotrophin receptor (p75NTR) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases. The death domain (DD) of p75NTR is an intracellular signaling hub and has been shown to interact with diverse adaptor proteins. Ho...