Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis

• Published in: bioRxiv
• Main Authors: He-Yun, Hsiao, Chun-Chia, Cheng, Yu-Ting, Chou, Cheng-Chin, Kuo, Wang, Wen-Ching, Bonifasius Putera Sampurna, Yi-Wen, Wang, Chun-Ling, Hsiao, Wu, Jing-Yiing, Kuan-Hao, Lin, Wan-Yu, Yang, Yu-Hsuan, Lin, Kong-Huai Gwee, Wang, Horng-Dar, Chiou-Hwa Yuh
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 04.03.2024
• Subjects: 6-Phosphofructokinase; Cancer therapies; Cell migration; Cell proliferation; Cirrhosis; Complementation; Glycolysis; Hepatitis; Hepatocellular carcinoma; Hepatoma; Inflammation; Interleukin 6; Liver cancer; Pentose phosphate pathway; Phosphofructokinase; Proteasomes; Stat3 protein; Tumorigenesis; Ubiquitination

Metabolic reprogramming is a pivotal characteristic of cancer, yet the intricate interplay between glycolysis and the pentose phosphate pathway (PPP) remains elusive. This study unveils the pivotal role of 6-phosphofructokinase liver type (PFKL) in glycolysis and ribose 5-phosphate isomerase A (RPIA...