A tripartite structure, the complex nuclear receptor element (cNRE), is a cis-regulatory module of viral origin required for atrial chamber preferential gene expression

• Published in: bioRxiv
• Main Authors: Luana Nunes Santos, Costa, Angela, Nikolov, Martin, Allysson Coelho Sampaio, Stockdale, Frank, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Dudczig, Stefanie, Vasconcelos, Michelle, Rosenthal, Nadia, Jusuf, Patricia Regina, Lopes-De-Oliveira, Paulo, Matos, Tatiana, Nikovits, Wiliam, Schubert, Michael, Ramialison, Mirana, Xavier-Neto, Jose
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 20.11.2021
• Subjects: Animal models; Gene expression; Gene regulation; Heart diseases; Muscle contraction; Myosin; Regulatory sequences; Ventricle

Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. Hence, myosin is under chamber-biased cis-regulatory control to achieve this functional...