Identifying Biomarkers of Retinal Pigment Epithelial Cell Stem Cell-derived RPE Cell Heterogeneity and Transplantation Efficacy

• Published in: bioRxiv
• Main Authors: Farjood, Farhad, Manos, Justine D, Wang, Yue, Williams, Anne L, Zhao, Cuiping, Borden, Susan, Alam, Nazia, Prusky, Glen, Temple, Sally, Stern, Jeffrey H, Boles, Nathan C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 23.11.2022
• Subjects: Age; Gene expression; Integration; Macular degeneration; Retina; Retinal degeneration; Retinal pigment epithelium; Stem cells; Transplantation

Transplantation of retinal pigment epithelial (RPE) cells holds great promise for patients with retinal degenerative diseases such as age-related macular degeneration. In-depth characterization of RPE cell product identity and critical quality attributes are needed to enhance efficacy and safety of...