A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

• Published in: bioRxiv
• Main Authors: Somarelli, Jason A, Rupprecht, Gabrielle, Erdem Altunel, Flamant, Etienne M, Rao, Sneha, Dharshan Sivaraj, Lazarides, Alexander L, Hoskinson, Sarah M, Sheth, Maya U, Cheng, Serene, So Young Kim, Ware, Kathryn E, Agarwal, Anika, Cullen, Mark M, Selmic, Laura E, Everitt, Jeffrey I, Mccall, Shannon J, Eward, Cindy, Eward, William C, Hsu, S David
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.10.2020
• Subjects: Bone cancer; Conflicts of interest; Cytotoxicity; Drug discovery; Drug screening; Nuclear transport; Osteosarcoma; Proteasomes; Xenografts

Abstract Purpose Osteosarcoma is a rare but aggressive bone cancer that occurs primarily in children. Like other rare cancers, treatment advances for osteosarcoma have stagnated, with little improvement in survival for the past several decades. Developing new treatments has been hampered by extensiv...