Dynamically regulated Focal adhesions coordinate endothelial cell remodelling in developing vasculature

• Published in: bioRxiv
• Main Authors: Tevin Chui-Ying Chau, Yordanov, Teodor E, Da Silva, Jason A, Patterson, Scott, Yap, Alpha S, Hogan, Benjamin M, Lagendijk, Anne Karine
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 03.02.2022
• Subjects: Actin; Adaptor proteins; Angiogenesis; Animal models; Blood flow; Cell size; Danio rerio; Elongation; Endothelial cells; Fertilization; Hemorrhage; Morphogenesis; Mutants; Phenotypes; Vinculin

The assembly of a mature vascular network involves the coordinated control of cell shape changes to regulate morphogenes is of a complex vascular network. Cellular changes include a process of endothelial cell (EC) elongation which is essential for establishing appropriately sized lumens during vess...