Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

• Published in: bioRxiv
• Main Authors: Martino, Nina, Ramos, Ramon Bossardi, Lu, Shuhan, Leyden, Kara, Tomaszek, Lindsay, Jaitovich, Ariel, Vincent, Peter A, Adam, Alejandro P
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.12.2020
• Subjects: Cytokine storm; Endothelium; Homeostasis; Inflammation; Interferon; Interleukin 6; Lethal dose; Lipopolysaccharides; Phenotypes; Proteasomes; Proteins; Renal failure; Stat3 protein; Ubiquitination

Abstract SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3iEKO) with a...