Pan-genotypic probe-based enrichment to improve efficiency of Hepatitis B virus sequencing

• Published in: bioRxiv
• Main Authors: Lumley, Sheila F, Jennings, Daisy, Waddilove, Elizabeth, Trebes, Amy, Delphin, Marion, Downs, Louise O, Macintyre-Crockett, George, Wu, Yanxia, Chaudron, Sandra, De Lara, Catherine, Chai, Haiting, Maponga, Tongai, Martin, Jacqueline, Collier, Jane, Ip, Camilla, Barnes, Ellie, Bonsall, David, Piazza, Paolo, M Azim Ansari, Matthews, Philippa C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.02.2023
• Subjects: Deoxyribonuclease; DNA probes; Genomes; Genotypes; Hepatitis B; Hybridization; Nuclease; Phages; Population genetics; Ribonuclease; RNA phages

Hepatitis B Virus (HBV) genome sequencing can be used to provide more complete genetic information at the population and individual level to shed light on the limitations of current interventions, and inform new strategies for elimination. HBV sequencing is challenging due to the partially dsDNA gen...