Bidirectional control of fear memories by the cerebellum through the ventrolateral periaqueductal grey

• Published in: bioRxiv
• Main Authors: Frontera, Jimena L, Hind Baba Aïssa, Sala, Romain William, Mailhes-Hamon, Caroline, Georgescu, Ioana Antoaneta, Léna, Clément, Popa, Daniela
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 20.02.2020
• Subjects: Amygdala; Anxiety; Associative learning; Cerebellum; Fear conditioning; Glutamatergic transmission; Parafascicular nucleus; Prefrontal cortex; Thalamus; γ-Aminobutyric acid

Fear conditioning is a form of associative learning that is known to involve brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fast...