The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties

• Published in: bioRxiv
• Main Authors: Clark, Andrew E, Adamson, Chelsea C, Carothers, Katelyn E, Roxas, Bryan Angelo P, Viswanathan, Vk, Vedantam, Gayatri
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 26.01.2022
• Subjects: Biofilms; Cell surface; Clostridioides difficile; Mutants; Phenotypes; Phylogeny; Proteomics; Sigma factor; Sporulation; Strains (organisms); Surface properties; Virulence factors

The alternative sigma factor SigL (Sigma-54) facilitates bacterial adaptation to the extracellular environment by modulating the expression of defined gene subsets. A homolog of the gene encoding SigL is conserved in the diarrheagenic pathogen Clostridioides difficile. To explore the contribution of...