Bacillus anthracis chain length, a virulence determinant, is regulated by a transmembrane Ser/Thr protein kinase PrkC

• Published in: bioRxiv
• Main Authors: Gupta, Meetu, Singh, Yogendra, Dhasmana, Neha, Kumar, Nishant, Gangwal, Aakriti, Keshavam, Chetkar Chandra, Singh, Lalit K, Sangwan, Nitika, Nashier, Payal, Biswas, Sagarika, Pomerantsev, Andrei P, Leppla, Stephen H
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 23.05.2020
• Subjects: Anthrax; Bacillus anthracis; Bacteria; Capillaries; Cell walls; Hydrolase; Hypoxia; Inoculation; Kinases; Localization; Peptidoglycans; Phenotypes; Protein kinase; Protein-serine/threonine kinase; Proteins; Septum; Therapeutic targets; Virulence; Virulence factors; Zoonoses

Anthrax is a zoonotic disease caused by Bacillus anthracis, a spore-forming pathogen that displays a chaining phenotype. It has been reported that in a mouse infection model, systemic inoculation with longer bacterial chains caused blockade in lung capillaries. The blockade resulted in increased pat...