Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function

• Published in: bioRxiv
• Main Authors: Cerda-Troncoso, Cristóbal, Grünenwald, Felipe, Arias-Muñoz, Eloísa, Cavieres, Viviana A, Caceres-Verschae, Albano, Hernández, Sergio, Gaete-Ramírez, Belén, Álvarez-Astudillo, Francisca, Acuña, Rodrigo A, Ostrowski, Matias, Burgos, Patricia V, Varas-Godoy, Manuel
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 04.02.2023
• Subjects: Chemoresistance; Chemotherapy; Cisplatin; DNA damage; Endosomes; Exosomes; Lysosomes; Ovarian cancer; Phenotypes; Rapamycin; Recovery of function; Vesicles

Ovarian cancer (OvCa) is an aggressive disease usually treated with cisplatin (CDDP)-based therapy. However, among the different types of cancers treated with CDDP, OvCa commonly develops chemoresistance to this treatment. The small extracellular vesicles (sEVs) play a central role in chemoresistanc...