Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6

• Published in: bioRxiv
• Main Authors: Ferguson, Kirsty M, Blin, Carla, Claudia Garcia Diaz, Bulstrode, Harry, Bressan, Raul, Mccarten, Katrina, Pollard, Steve
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.07.2022
• Subjects: Cell cycle; Cell proliferation; Forebrain; Forkhead protein; Foxg1 protein; FOXO3 protein; Glioblastoma; Molecular modelling; Neural stem cells; Stem cells; Tumor suppressor genes; Tumors; Vacuoles

The molecular mechanisms controlling the balance of quiescence and proliferation in adult neural stem cells (NSCs) are often deregulated in brain cancers such as glioblastoma (GBM). Previously, we reported that FOXG1, a forebrain-restricted neurodevelopmental transcription factor, is frequently upre...