SOCS3 limits endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin 6 signal in human umbilical vein endothelial cells

• Published in: bioRxiv
• Main Authors: Martino, Nina, Ramos, Ramon Bossardi, Chuy, Dareen, Tomaszek, Lindsay, Alejandro Pablo Adam
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.04.2022
• Subjects: Autocrine signalling; Cell activation; Cyclooxygenase-2; Cytokines; Endothelial cells; Endothelium; Glycoprotein gp130; Inflammation; Interferon; Interleukin 6; Lipopolysaccharides; mRNA; NF-κB protein; Stat1 protein; Stat3 protein; Thrombosis; Tissue factor; Toll-like receptors; Tumor necrosis factor; Tumor necrosis factor-TNF; Umbilical vein

Increased circulating levels of soluble interleukin (IL)-6 receptor α (sIL-6Rα) are commonly observed during inflammatory responses, allowing for IL-6 signaling to occur in cells that express the ubiquitous receptor subunit gp130 but not IL-6Rα, such as endothelial cells. Activation of Toll-like rec...