Hidden dynamics of proteasome autoregulation discovered by cryo-EM data-driven deep learning

• Published in: bioRxiv
• Main Authors: Wu, Zhaolong, Chen, Enbo, Zhang, Shuwen, Wei Li Wang, Ma, Yinping, Yuanchen Dong, Liu, Congcong, Chang-Cheng, Yin, Mao, Youdong
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 03.03.2022
• Subjects: Adenosine triphosphatase; Binding sites; Electron microscopy; Free energy; Proteasome 26S; Proteasomes; Proteolysis; Ubiquitin

The cellular functions are executed by macromolecular complexes in nonequilibrium dynamic processes, which exhibit a vast diversity of conformational states. Solving conformational continuum of important complexes at atomic level remains a key challenge in the methodology of computational biophysics...