The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells

• Published in: bioRxiv
• Main Authors: Herppich, Susanne, Beckstette, Michael, Huehn, Jochen
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.08.2021
• Subjects: Cell culture; Chemokines; Clonal deletion; Cytokines; Dendritic cells; Homing behavior; Immunological tolerance; Immunomodulation; Lymphocytes T; Microenvironments; Phenotypes; Spleen; Thymocytes; Thymus; Thymus gland

Thymic conventional dendritic cells (t DCs) are crucial for the development of T cells. A substantial fraction of t DCs originates extrathymically and migrates to the thymus. Here, these cells contribute to key processes of central tolerance like the clonal deletion of self reactive thymocytes and t...