Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

• Published in: bioRxiv
• Main Authors: Salinas-Rebolledo, Constanza, Blesa, Javier, Valenzuela-Nieto, Guillermo, Schwefel, David, Natalia Lopez Gonzalez Del Rey, Mendez-Ruette, Maxs, Burkhalter, Janine, Batiz, Luis Federico, Jara, Ronald, Obeso, Jose A, Chana-Cuevas, Pedro, Sapkota, Gopal P, Rojas-Fernandez, Alejandro
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.03.2024
• Subjects: Chimeras; Nanobodies; p97 Protein; Proteasome 26S; Proteasomes; Protein folding; Proteolysis; Ubiquitin-protein ligase

The p97 protein is a member of the AAA + family of ATPases. It is a mechanoenzyme that uses energy from ATP hydrolysis to promote protein unfolding and segregation actively. The unfolded products of p97 are presented to the 26S Proteasome for degradation. p97 substrate recognition is mediated by ada...