Drug combinations targeting FAK and MEK overcomes tumour heterogeneity in glioblastoma

• Published in: bioRxiv
• Main Authors: Furqan, Muhammad, Elliott, Richard Jr, Nagle, Peter, Dawson, John C, Malalmeh, Roza, Virginia Alvarez Garcia, Munro, Alison F, Drake, Camilla, Morrison, Gillian M, Pollard, Steven M, Ebner, Daniel, Brunton, Valerie G, Frame, Margaret C, Carragher, Neil O
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.12.2024
• Subjects: Apoptosis; Brain tumors; Cell viability; CRISPR; Drug resistance; Enzyme inhibitors; Focal adhesion kinase; Glioblastoma; Glioma; Intracellular signalling; Kinases; MEK inhibitors; Molecular modelling; Neuroimaging; Protein arrays; Signal transduction; Src protein; Therapeutic targets

Glioblastoma (GBM) is an aggressive brain tumour with limited treatment options and poor prognosis, largely due to its heterogeneity and the involvement of multiple intracellular signalling pathways that contribute to drug resistance. Standard therapies have not significantly improved patient outcom...