Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

• Published in: Malaria Journal
• Main Authors: Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Burgess, Freeman, White, Karen L, Shackleford, David M, Kathleen G O’Loughlin, Tang, Liang, Charman, Susan A, Mirsalis, Jon C, Guy, R Kiplin
• Format: Web Resource
• Language: English
• Published: Durham Research Square 25.01.2021
• Subjects: Binding; Bioavailability; Cytochrome; Drugs; Pharmacokinetics

Background: The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical candidate from late leads. Herein we present the pr...