Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

• Published in: bioRxiv
• Main Authors: Perez, Julio D, Dieck, Susanne Tom, Alvarez-Castelao, Beatriz, Ivy Cw Chan, Schuman, Erin M
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.10.2020
• Subjects: Axons; Dendrites; Gene expression; Glutamatergic transmission; Hippocampus; Interneurons; Labeling; Localization; Neurons; Proteomes; Synaptic plasticity; Transcriptomes; Translation; γ-Aminobutyric acid

Abstract The localization and translation of mRNAs to dendrites and axons maintains and modifies the local proteome of neurons, and is essential for synaptic plasticity. Although significant efforts have allowed the identification of localized mRNAs in excitatory neurons, it is still unclear whether...