Countering reproducibility issues in mathematical models with software engineering techniques: A case study using a one-dimensional mathematical model of the atrioventricular node

• Published in: bioRxiv
• Main Authors: Schölzel, Christopher, Blesius, Valeria, Ernst, Gernot, Goesmann, Alexander, Dominik, Andreas
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.03.2021
• Subjects: Automation; Case studies; Computer programs; Documentation; Experiments; Mathematical models; Reproducibility; Software; Software engineering

Abstract One should assume that in silico experiments in systems biology are less susceptible to reproducibility issues than their wet-lab counterparts, because they are free from natural biological variations and their environment can be fully controlled. However, recent studies show that only half...