Discovery of a Novel Polymer for Xeno-free, Long-term Culture of Human Pluripotent Stem Cell Expansion

• Published in: bioRxiv
• Main Authors: Thorpe, Jordan, Nasir, Aishah, Burroughs, Laurence, Meurs, Joris, Pijuan-Galito, Sara, Irvine, Derek J, Alexander, Morgan R, Denning, Chris
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.09.2020
• Subjects: Cell culture; Cell differentiation; Mass spectroscopy; Pluripotency; Polymers; Stem cells

Abstract Human pluripotent stem cells (hPSCs) can be expanded and differentiated in vitro into almost any adult tissue cell type, and thus have great potential as a source for cell therapies with biomedical application. In this study, a fully-defined polymer synthetic substrate is identified for hPS...