Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease

• Published in: bioRxiv
• Main Authors: Raval, Nakul Ravi, Gudmundsen, Frederik, Juhl, Morten, Ida Vang Andersen, Nikolaj Raahauge Speth, Videbæk, Annesofie, Petersen, Ida Nymann, Jens Damsgaard Mikkelsen, Patrick Macdonald Fisher, Herth, Matthias Manfred, Plavèn-Sigray, Pontus, Gitte Moos Knudsen, Palner, Mikael
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.08.2021
• Subjects: 6-Hydroxydopamine; Animal models; Autoradiography; Basal ganglia; Collaboration; Dopamine receptors; Forebrain; Medial forebrain bundle; Mesencephalon; Metabolism; Movement disorders; Neostriatum; Neurodegeneration; Neurodegenerative diseases; Parkinson's disease; Parkinsons disease; Positron emission tomography; Prefrontal cortex; Radioisotopes; Substantia nigra; Synaptic density

Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead to non-motor symptoms suc...