Histone chaperones exhibit conserved functionality in nucleosome remodeling

• Published in: bioRxiv
• Main Authors: Buzon, Pedro, Velazquez-Cruz, Alejandro, Gonzalez-Arzola, Katiuska, Diaz-Quintana, Antonio, Diaz-Moreno, Irene, Roos, Wouter H
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.01.2022
• Subjects: Chaperones; Chromatin remodeling; Cytochrome c; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA repair; Histones; Homeostasis; Nucleosomes; Transcription

Chromatin homeostasis mediates some of the most fundamental processes in the eukaryotic cell. In this regard, histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription. However, the dynamic nature of these processes has severely impeded their chara...