Genomic alterations in the YAP/TAZ pathway are associated with stem cell-like castration-resistant prostate cancer

• Published in: medRxiv : the preprint server for health sciences
• Main Authors: Roskes, Marjorie L, Martinez-Fundichely, Alexander, Cohen, Sandra, Balaban, Metin, Wong, Chen Khuan, Li, Weiling, Gonzalez, Tonatiuh A, Tehim, Anisha B, Xu, Hao, ElNaggar, Shahd, Myers, Matthew, Bareja, Rohan, Dorsaint, Princesca, Gorski, Kathryn, Asad, Muhammad, Assaad, Majd Al, Robinson, Brian D, Sigouros, Michael, Barnett, Ethan, Manohar, Jyothi, Tagawa, Scott, Nanus, David, Molina, Ana, Nauseef, Jones T, Sternberg, Cora N, Mosquera, Juan Miguel, Scher, Howard I, Sboner, Andrea, Raphael, Benjamin J, Chen, Yu, Khurana, Ekta
• Format: Journal Article
• Language: English
• Published: United States 02.07.2025

Castration-resistant prostate cancer (CRPC) is an aggressive disease exhibiting multiple epigenomic subtypes: androgen receptor-dependent CRPC-AR, and lineage plastic subtypes CRPC-SCL (stem cell-like), CRPC-WNT (Wnt-dependent), and CRPC-NE (neuroendocrine). By transcriptomic profiling of tissue, an...