Triple Positivity for Anti–Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti–Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 70; no. 11; pp. 1721 - 1731
• Main Authors: Verheul, Marije K., Böhringer, Stefan, Delft, Myrthe A. M., Jones, Jonathan D., Rigby, William F. C., Gan, Ryan W., Holers, V. Michael, Edison, Jess D., Deane, Kevin D., Janssen, Koen M. J., Westra, Johanna, Brink, Mikael, Rantapää‐Dahlqvist, Solbritt, Huizinga, Tom W. J., Helm‐van Mil, Annette H. M., Woude, Diane, Toes, Rene E. M., Trouw, Leendert A.
• Format: Journal Article
• Language: English
• Published: Atlanta Wiley Subscription Services, Inc 01.11.2018
• Subjects: Antibodies; Arthralgia; Arthritis; Autoantibodies; Carp; Citrulline; Data processing; Diagnosis; Diagnostic systems; Disease control; Identification methods; Immunoglobulins; Patients; Proteins; Rheumatoid arthritis; Rheumatoid factor; Sensitivity

Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these autoantibodies are mainly found in RA, their specificity is not optimal. It is therefore difficult to identify RA patients, espec...