Dynorphin A 1-17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography Ctandem mass spectrometry

• Published in: Analytical and bioanalytical chemistry Vol. 404; no. 10; pp. 3111 - 3121
• Main Authors: Morgan, M, Herath, H M D R, Cabot, P J, Shaw, P N, Hewavitharana, A K
• Format: Journal Article
• Language: English
• Published: 01.12.2012
• Subjects: Analgesia; Biotransformation; Fragments; Mass spectrometry; Mathematical analysis; Serums; Trypsin

Dynorphin A 1-17 (DYN A) is an endogenous neuropeptide that is of interest due to its diverse roles in analgesia, inflammation and addiction. Upon release, DYN A is subject to metabolism by a range of enzymes and its biotransformation is dependent on the site and environment into which it is release...