MPP super(+): Mechanism for Its Toxicity in Cerebellar Granule Cells

Cerebellar granule cells constitute the largest homogeneous neuronal population of the mammalian brain. However, they are not often used in studies that involve MPP super(+)-neurotoxicity. Currently, it is known that the toxicity of MPP super(+) in cerebellar granule cells as well as in other models...

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Published inMolecular neurobiology Vol. 30; no. 3; pp. 253 - 264
Main Authors Gonzalez-Polo, R A, Soler, G, Fuentes, J M
Format Journal Article
LanguageEnglish
Published 01.12.2004
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Summary:Cerebellar granule cells constitute the largest homogeneous neuronal population of the mammalian brain. However, they are not often used in studies that involve MPP super(+)-neurotoxicity. Currently, it is known that the toxicity of MPP super(+) in cerebellar granule cells as well as in other models, including dopaminergic cells, results from activation of the apoptotic machinery after an initial oxidative burst with mitochondrial damage and energetic failure. Therefore, cerebellar granule cells serve as a good model to investigate the MPP super(+) effects and to study in vitro the molecular mechanism implicated in the genesis of Parkinson's disease.
Bibliography:ObjectType-Article-2
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ISSN:0893-7648
1559-1182
DOI:10.1385/MN:30:3:253