Specific Enfuvirtide-Associated Mutational Pathways in HIV-1 Gp41 Are Significantly Correlated With an Increase in CD4 super(+) Cell Count, Despite Virological Failure

• Published in: The Journal of infectious diseases Vol. 197; no. 10; pp. 1408 - 1418
• Main Authors: Svicher, V, Aquaro, S, D'Arrigo, R, Artese, A, Dimonte, S, Alcaro, S, Santoro, M M, Di Perri, G, Lo Caputo, S, Bellagamba, R, Zaccarelli, M, Visco-Comandini, U, Antinori, A, Narciso, P
• Format: Journal Article
• Language: English
• Published: 15.05.2008
• Subjects: Human immunodeficiency virus 1

Background. Human immunodeficiency virus type 1 (HIV-1) gp41 is a crucial determinant for HIV-1 pathogenicity. We investigated the correlation of enfuvirtide (ENF)-associated gp41 mutational clusters with viroimmunological parameters, as well as the potential underlying mechanisms. Methods. A total...