De Novo Mutations in Moderate or Severe Intellectual Disability e1004772

• Published in: PLoS genetics Vol. 10; no. 10
• Main Authors: Hamdan, Fadi F, Srour, Myriam, Capo-Chichi, Jose-Mario, Daoud, Hussein, Nassif, Christina, Patry, Lysanne, Massicotte, Christine, Ambalavanan, Amirthagowri, Spiegelman, Dan, Diallo, Ousmane, Henrion, Edouard, Dionne-Laporte, Alexandre, Fougerat, Anne, Pshezhetsky, Alexey V, Venkateswaran, Sunita, Rouleau, Guy A, Michaud, Jacques L
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.10.2014
• Subjects: Data processing; Genomes; Genomics; Mutation; Proteins

Genetics is believed to have an important role in intellectual disability (ID). Recent studies have emphasized the involvement of de novo mutations (DNMs) in ID but the extent to which they contribute to its pathogenesis and the identity of the corresponding genes remain largely unknown. Here, we re...