Carotid dysfunction in senescent female mice is mediated by increased α1A-adrenoceptor activity and COX-derived vasoconstrictor prostanoids

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 324; no. 4; p. H417
• Main Authors: Costa, Tiago J, Barros, Paula R, Duarte, Diego A, Silva-Neto, Júlio A, Hott, Sara Cristina, Santos-Silva, Thamyris, Costa-Neto, Claudio M, Gomes, Felipe V, Akamine, Eliana H, McCarthy, Cameron G, Jimenez-Altayó, Francesc, Dantas, Ana Paula, Tostes, Rita C
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.04.2023
• Subjects: a-Adrenergic receptors; Adrenergic receptors; Aging; Blood vessels; Calcium (intracellular); Cardiovascular diseases; Carotid arteries; Carotid artery; Cyclooxygenase-1; Cyclooxygenase-2; Females; Hemodynamics; Hyperactivity; Muscles; Phenylephrine; Prostaglandins; Receptor density; Receptors (physiology); Senescence; Smooth muscle; Sodium nitroprusside; Vasoconstriction

α-Adrenergic receptors are crucial regulators of vascular hemodynamics and essential pharmacological targets for cardiovascular diseases. With aging, there is an increase in sympathetic activation, which could contribute to the progression of aging-associated cardiovascular dysfunction, including st...