Cpne1 deficiency preserves sperm motility under Ca 2+ channel blockade

• Published in: The Journal of reproduction and development Vol. 70; no. 5; p. 309
• Main Authors: Xie, Qiang, Zhang, Hanbin, Zhuang, Yuge, Liu, Jinsheng, Huang, Zicong, Zhang, Xiaoyuan, Ma, Ke, Liu, Wenyuan, Xie, Minyu, Huang, Chuyu, Zhong, Xiaojing, Chen, Feilong, Zou, Feng, Zhang, Wansong, Qiu, Chunming, Sun, Canbiao, Kang, Xiangjin, Chen, Zhenguo, Zhang, Guofei
• Format: Journal Article
• Language: English
• Published: Japan 01.10.2024
• Subjects: Animals; Azoospermia - genetics; Azoospermia - metabolism; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Calcium Signaling - drug effects; Humans; Male; Mice; Mice, Knockout; Phospholipid Transfer Proteins - genetics; Phospholipid Transfer Proteins - metabolism; Sperm Motility - drug effects; Spermatogenesis - drug effects; Spermatozoa - drug effects; Spermatozoa - metabolism; Testis - drug effects; Testis - metabolism; Copine1; Sperm motility; Calcium ion; Spermatogenesis; Male infertility

Calcium ions (Ca ) play crucial roles in sperm motility and fertilization. The copine (CPNE) family comprises several Ca -dependent phospholipid-binding proteins. Of these, CPNE1 is extensively expressed in mammalian tissues; however, its precise role in testicular development and spermatogenesis is...