Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y 13 receptor and nitric oxide signaling

• Published in: Basic research in cardiology Vol. 117; no. 1; p. 46
• Main Authors: Jiao, Tong, Collado, Aida, Mahdi, Ali, Jurga, Juliane, Tengbom, John, Saleh, Nawzad, Verouhis, Dinos, Böhm, Felix, Zhou, Zhichao, Yang, Jiangning, Pernow, John
• Format: Journal Article
• Language: English
• Published: Germany 16.09.2022
• Subjects: Adenosine Triphosphate; Animals; Cyclic GMP-Dependent Protein Kinases; Erythrocytes - metabolism; Humans; Myocardial Infarction - prevention & control; Myocardial Infarction - therapy; Myocardial Reperfusion Injury - prevention & control; Myocardial Reperfusion Injury - therapy; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - metabolism; Nitric Oxide Synthase; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2 - metabolism; Soluble Guanylyl Cyclase; ST Elevation Myocardial Infarction - metabolism; Ischemia–reperfusion injury; ST-elevation myocardial infarction; Red blood cells; Nitric oxide; Soluble guanylyl cyclase; Purinergic; ATP

Red blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. It remains unknown whether such beneficial effects of RBCs are protective in patients with acute myocardial infarction. We investigated whether RBCs from...