Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis e1002269

• Published in: PLoS biology Vol. 13; no. 10
• Main Authors: Li, Caiyi C, Munitic, Ivana, Mittelstadt, Paul R, Castro, Ehydel, Ashwell, Jonathan D
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.10.2015
• Subjects: Cytokines; Dendritic cells; Experiments; Flow cytometry; Inflammation; Medical research; Mortality; Rodents; Sepsis; Software; Statistical analysis

Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients and in experimental sepsis models, but the role of...