Alpha-1抗胰蛋白酶对小鼠及人类酒精相关肝病的影响

<正>【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响 (作者Grander C等) 酒精相关肝病 (ALD) 是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶 (AAT) 在诸多临床前和临床试验中显示出强大的抗炎活性,本研究旨在探索AAT在ALD中发挥的作用。来自奥地利因斯布鲁克医科大学消化内科的Grander等进行了一项包括人类与小鼠实验两部分的研究。在人类研究中,随机选择512例肝硬化患者,对其进行临床特征分析,比较酒精性肝硬化患者与其他肝病病因肝硬化患者的生存率、临床特征及生化指标 (包括血清AAT浓度) 的差异。在酒精性肝...

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Published inLinchuang gandanbing zazhi Vol. 36; no. 10; p. 2273
Main Authors 巴桃桃, 高沿航, GRANDER, C, Schaefer, B, SCHW?RZLER J
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.01.2020
吉林大学第一医院感染病中心肝病科
Online AccessGet full text
ISSN1001-5256
2097-3497

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Abstract <正>【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响 (作者Grander C等) 酒精相关肝病 (ALD) 是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶 (AAT) 在诸多临床前和临床试验中显示出强大的抗炎活性,本研究旨在探索AAT在ALD中发挥的作用。来自奥地利因斯布鲁克医科大学消化内科的Grander等进行了一项包括人类与小鼠实验两部分的研究。在人类研究中,随机选择512例肝硬化患者,对其进行临床特征分析,比较酒精性肝硬化患者与其他肝病病因肝硬化患者的生存率、临床特征及生化指标 (包括血清AAT浓度) 的差异。在酒精性肝硬化患者中,与血清AAT浓度高于120 mg/dl相比,血清AAT浓度低于120 mg/dl的患者发生死亡/肝移植的风险显著增加。多变量Cox回归分析显示,低血清AAT浓度是肝硬化患者独立的生存/移植预测因子。
AbstractList <正>【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响 (作者Grander C等) 酒精相关肝病 (ALD) 是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶 (AAT) 在诸多临床前和临床试验中显示出强大的抗炎活性,本研究旨在探索AAT在ALD中发挥的作用。来自奥地利因斯布鲁克医科大学消化内科的Grander等进行了一项包括人类与小鼠实验两部分的研究。在人类研究中,随机选择512例肝硬化患者,对其进行临床特征分析,比较酒精性肝硬化患者与其他肝病病因肝硬化患者的生存率、临床特征及生化指标 (包括血清AAT浓度) 的差异。在酒精性肝硬化患者中,与血清AAT浓度高于120 mg/dl相比,血清AAT浓度低于120 mg/dl的患者发生死亡/肝移植的风险显著增加。多变量Cox回归分析显示,低血清AAT浓度是肝硬化患者独立的生存/移植预测因子。
Author 高沿航
巴桃桃
SCHW?RZLER J
Schaefer, B
GRANDER, C
AuthorAffiliation 吉林大学第一医院感染病中心肝病科
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吉林大学第一医院感染病中心肝病科
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Snippet <正>【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响 (作者Grander C等) 酒精相关肝病 (ALD) 是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶 (AAT)...
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Title Alpha-1抗胰蛋白酶对小鼠及人类酒精相关肝病的影响
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