Regulation of glioblastoma cell invasion by PKCi and RhoB

• Published in: Oncogene Vol. 27; no. 25; pp. 3587 - 3595
• Main Authors: BALDWIN, R. M, PAROLIN, D. A. E, LORIMER, I. A. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 05.06.2008
• Subjects: Biological and medical sciences; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Fundamental and applied biological sciences. Psychology; Medical sciences; Molecular and cellular biology; Neurology; Tumors of the nervous system. Phacomatoses; Nervous system diseases; Enzyme; Transferases; Glioblastoma; PTEN; Malignant tumor; Carcinogenesis; RhoB; Malignant glioma; Regulation(control); atypical PKC; Kinase; Central nervous system disease; PI 3-kinase; Cancer; Tumor suppressor gene

Glioblastoma multiforme is the most aggressive form of primary brain tumor and remains largely incurable, in large part, due to its highly invasive nature. The phosphoinositide (PI) 3-kinase pathway is often constitutively active in these tumors due to activating mutations in the epidermal growth fa...