Spontaneous Harderian Gland Adenocarcinoma in a Female F344 Rat

Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epitheli...

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Published inJournal of toxicologic pathology Vol. 27; no. 2; p. 139
Main Authors Senoh, Hideki, Katagiri, Taku, Takanobu, Kenji, Umeda, Yumi, Aiso, Shigetoshi, Fukushima, Shoji
Format Journal Article
LanguageEnglish
Japanese
Published Tokyo Japan Science and Technology Agency 01.04.2014
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Abstract Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited in most areas of the tumor. The tumor cells were pleomorphic and atypical. In one part of the tumor, poorly differentiated areas were found. This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor.
AbstractList Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited in most areas of the tumor. The tumor cells were pleomorphic and atypical. In one part of the tumor, poorly differentiated areas were found. This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor.
Author Senoh, Hideki
Takanobu, Kenji
Aiso, Shigetoshi
Umeda, Yumi
Katagiri, Taku
Fukushima, Shoji
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