NEDDylation Is Essential for Kaposi's Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target e1004771

• Published in: PLoS pathogens Vol. 11; no. 3
• Main Authors: Hughes, David J, Wood, Jennifer J, Jackson, Brian R, Baquero-Pérez, Belinda, Whitehouse, Adrian
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.03.2015
• Subjects: Cancer; Cancer therapies; Colleges & universities; Cytotoxicity; Deoxyribonucleic acid; DNA; Gene expression; Genomes; Human herpesvirus 8; Infections; Kaposi's sarcoma-associated herpesvirus; Kaposis sarcoma; Laboratories; Lymphoma; Medical research; Proteins

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients. For many non-viral malignancies, therapeutically targeting the ubiquitin proteas...