ILF3 contributes to the establishment of the antiviral type I interferon program

• Published in: bioRxiv
• Main Authors: Watson, Samir F, Bellora, Nicolas, Macias, Sara
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.10.2019
• Subjects: Double-stranded RNA; Inflammation; Interferon; Next-generation sequencing; Transcription; Translation

Upon detection of viral infections, cells activate the expression of type I interferons (IFNs) and pro-inflammatory cytokines to control viral dissemination. As part of their antiviral response, cells also trigger the translational shutoff response which prevents translation of viral mRNAs and cellu...