Flow-independent accumulation of motor-competent non-muscle myosin II in the contractile ring is essential for cytokinesis

• Published in: bioRxiv
• Main Authors: Daniel Sampaio Osorio, Fung Yi Chan, Saramago, Joana, Leite, Joana, Silva, Ana Marta, Sobral, Ana Filipa, Gassmann, Reto, Carvalho, Ana Xavier
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 31.05.2018
• Subjects: Actin; Actomyosin; Cytokinesis; Embryos; Filaments; Genomes; Motor activity; Muscle contraction; Myosin

Cytokinesis in animal cells requires the assembly of a contractile actomyosin ring, whose subsequent constriction physically separates the two daughter cells. Non-muscle myosin II (myosin) is essential for cytokinesis, but the role of its motor activity remains poorly defined. Here, we examine cytok...