Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer

• Published in: bioRxiv
• Main Authors: Fregoso, Santiago P, Dwyer, Brett E, Franco, Santos J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.07.2018
• Subjects: Binding sites; Enhancers; Forebrain; Homeobox; Neocortex; Neural stem cells; Transcription factors

During neocortical development, neurons are produced by a diverse pool of neural progenitors. A subset of progenitors express the Cux2 gene and are fate-restricted to produce certain neuronal subtypes, but the upstream pathways that specify these progenitor fates remain unknown. To uncover the trans...