Connecting genetic risk to disease endpoints through the human blood plasma proteome

• Published in: bioRxiv
• Main Authors: Suhre, Karsten, Arnold, Matthias, Bhagwat, Aditya, Cotton, Richard J, Engelke, Rudolf, Laser, Annika, Raffler, Johannes, Sarwath, Hina, Thareja, Gaurav, Robert Kirk Delisle, Gold, Larry, Pezer, Marija, Lauc, Gordan, El-Din Selim, Mohammed A, Mook-Kanamori, Dennis O, Al-Dous, Eman K, Mohamoud, Yasmin A, Malek, Joel, Strauch, Konstantin, Grallert, Harald, Peters, Annette, Kastenmuller, Gabi, Gieger, Christian, Graumann, Johannes
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.11.2016
• Subjects: Alzheimer's disease; Aptamers; Autoimmune diseases; Cardiovascular diseases; Gene mapping; Genome-wide association studies; Genomes; Health risk assessment; Neurodegenerative diseases; Peptide mapping; Phenotypes; Proteins; Proteomics; Single-nucleotide polymorphism; Therapeutic applications

Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence for mapping disease associations and translating them into clinical applications. However, although hundreds of genetic risk variants have been associated w...